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Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

机译:全基因组关联研究(GWAS)识别的疾病风险等位基因不会影响人类寿命

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摘要

A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from the general population carry the same number of disease risk alleles as young controls. Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease.
机译:测试了一组目前已知的等位基因,这些基因增加了通过全基因组关联研究确定的冠状动脉疾病,癌症和2型糖尿病的风险与人类寿命的相容性。在这里,我们显示了来自长寿家庭的非亲属兄弟姐妹和来自普通人群的年龄超过85岁的单身人士携带的疾病风险等位基因数量与年轻对照组相同。该研究人群的寿命不受常见疾病风险等位基因的累积效应影响。

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